Intranasal (IN) vaccination of calves for respiratory disease has several advantages.
IN vaccines stimulate a stronger local immune response because the modified live microorganisms are delivered directly to the mucosa lining the inner surface of the nose. This mimics a natural infection and will cause the body to release antibodies directly onto the mucosa. These mucosal antibodies will remain in the nose and bind to any pathogens that try to enter the body, thus successfully preventing infection.
IN vaccines also stimulate the production of interferon, which is a protein important for a general, non-specific immune response. Interferon production occurs rapidly, sometimes as soon as 24 hours after vaccination, while antibody production generally takes longer to develop. Thus, cattle are protected in two different ways just a short time after vaccination.
Since IN vaccines provide such rapid protection, they are especially beneficial for young calves during a time of stress. Weaning is one of the most stressful times in a calf’s life due to nutritional changes, moving to a new environment, and learning how to interact socially. Intranasal vaccination is a more efficient means of obtaining protection from common respiratory pathogens, thereby sparing valuable metabolic resources for growth.
There are currently multiple intranasal vaccines on the market. Inforce 3, TSV-2, and Nasalgen are all IN vaccines for use against viral causes of respiratory disease. The newly introduced Once PMH IN vaccine is labeled for use against the two most common causes of bacterial respiratory disease: Mannheimia haemolytica and Pasteurella multocida.
Once PHM IN is labeled for healthy animals 1 week of age or older, including pregnant animals. Inforce 3, TSV-2, and Nasalgen are safe for all ages including newborn calves and pregnant cows. IN vaccines can be safely repeated when the risk of respiratory disease is high. They can also be followed by injectable respiratory vaccines for more complete viral protection.
You should always consult your veterinarian before changing any vaccination protocols.
How Can ANIMART Help?
ANIMART is committed to the success of our producers. We strive to actively promote the health and well-being of our clients’ animals by preventing disease whenever possible. ANIMART veterinarians are well equipped to build a BRD prevention program for your young calves.
Dr. Vicky Lauer
ANIMART Professional Services Veterinarian